A Missing Genetic Sequence Leads To Orange Fur In Cats. Could It Be Responsible For Behavioral Differences Too?

Scientists have uncovered the elusive mechanisms behind coat color expression, opening the door to a new question: is fur pigment connected to personality?

When Professor Hiroyuki Sasaki retired, he wasn’t done with science. He just wanted to use it to better understand his cats.

The Japanese geneticist raised more than $73,000 from Japanese and international cat lovers and put together a team, including partners from the US. Then he began the hard work of scrutinizing feline DNA to find out why some cats are orange, and why most all-orange cats are male while virtually all calico and tortoiseshell cats, whose coats have splotches of orange, are female.

It turns out there’s no genetic instruction telling the fur to take on an orange pigment — it’s the absence of a segment of DNA, which governs pigment production, that does it.

In other words, ginger cats are mutants.

Most fully-orange cats are male because the mutation removes the DNA segment in the X chromosome. As males have X and Y chromosomes, they only need the mutation in the single X chromosome for their coats to express in that shade.

Lots of cat lovers swear that coat color and temperament are connected.

Females have an XX chromosomal arrangement, so they need the mutation in both chromosomes to turn tangerine. If the mutation only shows up in one chromosome, you get patches of the color instead of a consistent coat.

That explains why 80 percent of ginger cats are male, and why only one in 3,000 calicos and tortoiseshells are male. A male cat would need an extra X chromosome, XXY, to be born with a calico or tortoiseshell coat. One of the side effects, however, is sterility.

Scientists estimate only one in a thousand male calicos/tortoiseshells can reproduce and pass their unique mutations on.

It’s not just coat color either. The mutation impacts skin and eye color, which is why a ginger cat might have a pink nose compared to the terracotta shade of a void cat or a silver tabby.

Are orange cats really more friendly and silly?

So how does this relate to temperament, and the many people who attest to a particular personality associated with orange cats? Some people say ginger tabbies are more loyal, affectionate and social than cats of other coat colors, but they’re also more prone to doing boneheaded things.

The stereotypes have picked up steam online, where people often share memes depicting orange felines as earnestly derpy, but they may be on to something — or at least, it can’t be ruled out until we know more.

Ginger cats are not the sharpest claw on the paw, according to popular memes.

Because of the missing piece of genetic code, a specific gene, ARHGAP36, isn’t “expressed.” Like so many genes, scientists don’t fully understand everything ARHGAP36 impacts, or how alterations can lead to unexpected changes elsewhere.

“Many cat owners swear by the idea that different coat colours and patterns are linked with different personalities,” Sasaki told the BBC. “There’s no scientific evidence for this yet, but it’s an intriguing idea and one I’d love to explore further.”

Header image via Pexels

Wordless Wednesday: They Rule The Night

Cats were built by mother nature to stalk by starlight.

From the African savannas to the Andean mountains, the jungles of the Amazon to the Hollywood hills, and everywhere in suburban America, cats of all types and sizes prowl the night. With eyes that are up to eight times more sensitive in the dark, incredibly sensitive hearing, and whiskers that can pick up the slightest change in air density, felids were built by mother nature to stalk by starlight.

Some cat species are crepuscular, some are nocturnal, but as ambush predators, they’re all at their best when hunting under the cover of darkness.

Image credits, top to bottom: Per Karlson/PVKFoto, Reddit r/natureisf***inglit, Cockscomb Basin Wildlife Preserve, Wikimedia Commons, Steve Winter/National Geographic, National Park Service, Colorado Parks and Wildlife

Point/Counterpoint: ‘You Don’t Tell Me When To Sleep, Human!’ vs ‘A Consistent Bedtime Is Important!’

Buddy the Cat argues that a consistent bedtime is key to feeling good and healthy, while Buddy the Cat counters that stupid humans don’t tell him when to sleep, HE decides. Who’s right, Buddy or Buddy?

A Consistent Bedtime Is Important

What are you doing, human? It’s bedtime! Mow mow! You’re supposed to be in this bed and laying down so I can use your face as a pillow, drape myself across you, or burrow comfortably against your side to soak up body heat.

What am I supposed to do without a human sleeping substrate? How can any cat be expected to sleep like this? I know you claim there are so called “stray cats” who don’t have humans, but that is preposterous and I don’t believe it.

Let’s go! I read an article saying it’s very important to have a regular sleep schedule. Well, actually, I just saw the headline, but I got the gist of it, which is that you have to go to bed right meow!

You Don’t Tell Me When To Sleep, Human!

Sleep? Now? That’s ridiculous.

No, I have shadows to chase, toys to kick around and I really wanted to get into redecorating things around here, because they’re looking a little too orderly for my tastes.

Go ahead, go to bed. In a few minutes I’ll cry outside the bedroom door until you get out of bed and open it, then I’ll decide I don’t want to go in after all. I’ll do that two, maybe three more times just because I can.

Oh, you thought I was settling in? Nah. I have a bowl of water to splash all over the place, then I’ll cry until you get up again and refill it, and when you get back into bed for the fifth or sixth time, I’ll cry incessantly again because my dry food bowl is empty, meaning there’s plenty of food but it’s all pushed up to the sides.

Do not forget our pre-slumber ritual! You have to scratch my chin while I purr and you tell me what a good boy I am. Then you have to scratch the top of my head while I purr and you tell me what a good boy I am.

After that, maybe I’ll sleep. We’ll see.

Does The Budster Love Me?

“Love is a strong word, human. I prefer ‘tolerate.’ On days when you anticipate my snack cravings before I verbalize them, you could maybe say I’m fond of you.”

Newsweek has an interesting interview with a cat behaviorist on the subject of whether cats love their humans.

Chantal Howard, a certified cat trainer with Feline Focus Training in Ottawa, told the magazine there are nine primary behaviors that indicate — or confirm — a house tiger loves his or her person. Most of these won’t be new to PITB readers, who are of course among the most cat-savvy people out there and have magnificent taste in cat blogs, but it’s still a handy way to ascertain how your feline overlord feels about you.

So how does Buddy do according to this checklist? Let’s see:

Headbutting: ✅ His Lordship is quite fond of headbutting me and favors me with dozens of headbutts throughout the day, ensuring his pheromones remain on me. You know, in case some other cat somehow comes wandering in and there’s a dispute about which furball owns me.
Kneading: ✅ Considering the fact that I’ve had to toss quite a few t-shirts because of claw rips, I’d say that’s a yes. At least he doesn’t knead my face anymore, as he liked to do when he was a kitten and would take his perch on my shoulder, nuzzle up to my neck and make biscuits against my beard.
Purring: ✅ Nine times out of 10, Buddy’s purr is inaudible, but it’s there. It’s a bit odd that such a talkative, loud cat barely makes a buzz. He likes to lay on my chest and purr up a storm while I rub his head and tell him he’s got admirers all over the world.
Chirping: ✅ Yes! In fact, chirps and trills make up a significant part of the Buddinese language. While meows can be positive, negative or demanding (“I can see the bottom of my bowl! This is an outrage, human!”), trills and chirps are always happy sounds.
Nipping: ✅ Unfortunately, yes.
Licking: ✅ He grooms my hair and my beard, and when I shave he licks my face, which is pretty gross.
Bringing Gifts: ❌ Negative. Then again, what kind of gifts can he bring me when he’s an indoor cat and doesn’t fully understand the concept of hunting?
Exposing Belly: ❌ Does he expose his belly? Yes. Does he feel comfortable enough to snooze in my lap with his belly exposed? Of course. Does he want me to give him belly rubs? No, he emphatically does not. The primordial pouch is not to be touched!
Tail Position: ✅ One of the most awesome things is the fact that Bud’s tail goes immediately into happy mode when I say “Hi, Bud!”, when I hold my hand out for a headbutt, and when I talk to him in general. His tail quivers with excitement when we play with the laser pointer or his favorite toy, and when he catches the first whiff of catnip.

So that’s 7 of 9, or 7 of 8 if we count gifts as N/A due to Bud’s hilarious ineptitude when it comes to even grasping the concept of hunting.

Bud has been known to throw up from excitement when I return from vacation, he often naps by the door when I go out, he talks to me constantly, and he’s rarely more than three or four feet away from me at any given time. All those things, plus our strong bond, have proven to me that he does love me, but it’s also nice to confirm it with a behaviorist’s criteria.

How does your cat perform on the checklist? Don’t forget to share your results in the comments.

Report: Trump Officials Added Buddy The Cat To Houthi War Plans Text Group

The mercurial tabby cat tried to convince Secretary of Defense Pete Hegseth to bomb the Isle of Dogs, White House officials grudglingly acknowledged.

The controversy over leaked war plans expanded Monday after new reports revealed a journalist was not the only outsider added to a text group between senior members of the administration.

Buddy the Cat, a domestic tabby from New York, was also invited to the group and subsequently made privy to classified information, the White House acknowledged.

While Atlantic editor Jeffrey Goldberg observed the text conversation between senior members of the Trump administration without participating in the exchange, sources say Buddy the Cat tried to convince Pete Hegseth, the defense secretary, to bomb London’s Isle of Dogs.

In addition, White House press secretary Karoline Leavitt grudgingly acknowledged Buddy was able to convince Hegseth and Kristi Noem, the homeland security secretary, to send federal agents to the home of a cat named Smudge, describing him as “a gastronomic terrorist who hates America and will stop at nothing to claim all the snacks for himself.”

When administration officials denied knowing Buddy the Cat, social media users began unearthing dozens of photos of the feline associating with national leaders. No one knows how deep the conspiracy goes.

Initially White House officials denied the feline was given access to the text group, with Leavitt calling it “an egregious example of the fake news media inventing absurd stories,” but they were forced to acknowledge the veracity of the incident when confronted with copies of the exchange.

“Folks, we are cleared for go, CENTCOM has given us the green light for the fifth strike package,” Hegseth wrote. “F-18 launch imminent.”

“Are we just going to ignore the Isle of Dogs?” Buddy the Cat texted in response.

The text caused confusion, with several senior officials speculating on the sender’s identity.

“The contact says ‘BTC.’ Who the heck is this?” Director of National Intelligence Tulsi Gabbard asked.

“It’s [US Marine Corps] Gen. [Barrington T.] Caldwell,” replied Mike Waltz, the National Security Advisor. “Got to be.”

Noem also initially tried to distance herself from the scandal by claiming she didn’t know Buddy, but photographs soon emerged of the tabby cat lounging on the podium while she spoke at CPAC in 2003.

It’s not clear how senior White House officials were convinced by a cat that a London neighborhood was related to an Iran-backed Shia militia in Yemen, but an anonymous official credited Buddy the Cat for “being very convincing. We all thought he was the general.”

While the feline’s suggestion to bomb the London neighborhood was co-signed by Hegseth, it was ultimately rejected by CENTCOM, which noted the UK is an allied country and there was no indication “terrorist dogs” populated the London neighborhood.

More successful was Buddy the Cat’s suggestion to send a federal strike team to the home of Smudge, his archrival.

The chonky cat screeched his innocence after heavily armed and armored federal agents smashed the door down and found him mid-bowel movement in his litter box.

“1337et: Agents have located the CHONKY little jerk in his domicile, where they found fresh explosive materials in his litter box and a suspiciously well-stocked cupboard,” Buddy wrote to the Houthi PC Small Group.

“Congrats, general!” Waltz wrote, while Noem called the arrest “a major win for American freedom and security.”

Reporters, former military officers and intelligence officials criticized the leak, pointing out that if a cat could get access to highly sensitive war plans — and influence them in real time — America’s enemies could do the same. But White House officials pushed back on the criticism, saying it was overblown.

“So someone put a cat on a text chain,” Leavitt said, snapping at a reporter during a press briefing. “So what? You guys are, like, being so dramatic!”