After 10,000 Years, Dire Wolves Walk The Earth Again

The surprise announcement came from Colossal Biosciences, a company best known for its project to bring back the woolly mammoth.

A US biotech company shocked the world Monday when it announced the births of three dire wolf puppies, bringing back a species that hasn’t lived for more than ten millennia.

Or a version of that species, at least.

Scientists with Colossal Biosciences extracted DNA “from a 13,000 year old tooth and a 72,000 year old skull and made healthy dire wolf puppies,” Colossal CEO Ben Lamm said in a statement.

Of course, it wasn’t that simple.

The dire wolf, Aenocyon dirus, was heavier, stockier and had thicker fur than modern-day gray wolves. In addition, its bite was incredibly strong, generating more force than any living species of canid.

To create the dire wolf puppies, Colossal used the genomes reconstructed from the tooth and skull, spliced them with gray wolf DNA, and made 20 gene edits in 14 genes. Healthy embryos were implanted in three surrogates — large, mixed-breed dogs — and were successfully delivered.

Romulus, one of two male dire wolf pups born late in 2024. Credit: Colossal Biosciences
Remus, who was born at the same time as Romulus. Credit: Colossal Biosciences

Whether the new puppies are officially dire wolves is up for debate and beyond the scope of this post, but just like humans and chimpanzees share 98.7 percent of their DNA, dire wolves and gray wolves share 99.5 percent of their DNA.

The species also existed concurrently with gray wolves and there was interbreeding between the populations, meaning gray wolves already have dire wolf lineage.

As a result, the puppies may be more dire wolf than some are willing to admit. Just how far a “de-extinction” project has to go for the animals to qualify as their namesakes will be debated for years, and there are innumerable questions for which we won’t have answers until the pups grow and scientists monitor their behavior in addition to their physical health.

They won’t behave precisely the way their ancestors did, since they are growing up in a captive environment with teams of specialists constantly monitoring them. The wolves are “essentially living the Ritz Carlton lifestyle of a wolf. They can’t get a splinter without us knowing about it,” Colossal’s chief science officer, Beth Shapiro, told the New York Times.

Whether bringing back dire wolves is a “good” thing is also a topic for another day, at least as far as this post goes. You may disagree, and feel free to say so in the comments, but this is a subject you could write half a library of books on, encompassing ecological, moral and philosophical questions that don’t have easy answers.

It’s made even more complex by the situation we find ourselves in, with our own behavior and relentless expansion killing off more than 70 percent of the world’s wildlife since 1970, according to the World Wildlife Fund. The company wants to use its technology to help critically endangered species, like the red fox, avoid extinction.

Colossal has partnered with leaders in the fields of genetics and bioethics, as well as organizations that specialize in animal welfare. The puppies are in a sizable, custom-built facility in an undisclosed location, secured by “zoo grade” barriers, and the company enlisted the help of the SPCA to create an environment appropriate for them. Colossal says their care regimen will include socialization and the development of pack dynamics.

A newborn dire wolf pup. Credit: Colossal Biosciences

The company has well-publicized projects to bring back woolly mammoths and the dodo, and ultimately, its founders say they want to restore balance in places where apex predators have been brought to extinction by human activity.

“This project demonstrates the awesome potential for advances in genetic engineering and reproductive technologies to recreate lost diversity,” Andrew Pask, a Colossal board member and professor of biosciences at the University of Melbourne, said in a statement. “Apex predators are critical to stabilizing entire ecosystems and their loss from the landscape can have profound impacts on biodiversity.”


The pups are named Romulus, Remus and Khaleesi. That last name is in homage to the character Daenerys Targaryen (Emilia Clarke) from the book series A Song of Ice and Fire, and Game of Thrones, the television adaptation. Dire wolves play a major part in the narrative, and the series is credited with bringing the long-extinct animals back into the popular imagination.

Jon Snow (Kit Harrington) discovers an orphaned dire wolf pup in the first season of Game of Thrones. The pup, who grows into a fierce and massive adult wolf named Ghost, plays a pivotal role in many major events in the series. Credit: HBO
Khaleesi, a female dire wolf, named after the character Daenerys Targaryen from Game of Thrones. Credit: Colossal Biosciences

‘Swift And Lethal’: Cats Have No Defense Against Bird Flu, And It Keeps Showing Up In Their Food

Bird flu is killing cats domestic and wild, in captivity and in nature. Experts are sounding the alarm, warning people not to feed their cats raw food, allow them to drink milk, or let them roam outside where they can easily catch the virus by going after small prey.

Highly Pathogenic Avian Influenza, the clinical name for bird flu, is a danger to all animals, but for cats it’s a virtual death sentence.

Only a handful have survived infection thanks primarily to early diagnosis, intervention and round-the-clock veterinary care. In the vast majority of cases, the virus burns through its feline victims in three or four days.

Bird flu has become even more deadly for felines of late. Of the 126 domestic cats killed by H5N1 since 2022, according to the US Department of Agriculture, half of them have have died in 2025 — and it’s only been three months.

Notably, that total doesn’t include captive wild cats and big cats, such as the 20 pumas, bobcats, tigers and other felids who succumbed to the virus at the Wild Felid Advocacy Center, a sanctuary in Washington state. Nor does it include cats living in the wild, like two pumas in the same state that died in December.

To appreciate the true scope of the problem, the more illuminating statistic may be 82 million, which is the number of chickens “culled” — killed — in the US since 2022 because they were infected or raised at facilities where other birds tested positive for the virus.

Factory farming compounds the matter: more than 1.6 million egg-laying hens and 337,000 “pullets” — chickens less than a year old — were “depopulated” at a single facility in Texas last year. As staggering as those numbers are, Texas’s Department of Agriculture noted the figure merely “accounts for approximately 3.6% of the company’s total flock.”

Per the USDA:

“To provide context on the overall size of the U.S. poultry flock, there are more than 378.5 million egg-laying chickens in the United States. In 2023, more than 9.4 billion broiler chickens and 218 million turkeys were processed in the United States.”

If there ever was an example of putting too many eggs in one basket, this is it. American food supplies are vulnerable with so much concentrated in the hands of so few companies, a lesson the general public is learning the hard way now after eggs peaked at record prices last month. Things have cooled off a bit since then, but shoppers aren’t getting any benefit as grocery chains continue to charge a premium: the nationwide average for a dozen eggs was $5.90 in February, but stores in some states are still charging $10 or more.

It also raises questions about the sustainability and ethics of eating animals. Humans slaughter more than 75 billion chickens every year, and projections indicate there will be three billion more of us by the mid-2080s.

Meat from infected chickens can still end up in your cat’s bowl

Media reports about culling give the impression that those birds are removed from the food chain, but that’s not entirely true. The pet food industry has always cut corners by harvesting meat not fit for human consumption, a category that includes everything from the carcasses of sick animals, to “meat by-products” that can include beaks, hooves, eyes, hearts and other organs.

So while the culled chickens won’t show up in shrink wrap at the grocery store, they are making it into the pet food supply chain. Most pet food is “rendered,” cooked at such high temperatures that potential pathogens have been destroyed.

But an increasingly bigger slice of the market has been claimed by companies selling “premium” raw food — and that’s been the primary infection vector for domestic cats, particularly indoor cats who otherwise would have little or no exposure to the virus. (Cats who spend time outdoors can catch bird flu by preying on infected animals, just as wild cats do, and barn cats have caught it by drinking the milk of infected cattle.)

Cats are mostly lactose intolerant, and should not be given cow’s milk, despite the common misconception that it’s healthy for them.

“The animals that were depopulated could potentially have ended up in the food chain for pets,” Laura Goodman, an assistant professor at Cornell University’s Baker Institute for Animal Health, told NBC News. “It’s not uncommon for substandard meat to end up in the pet food chain.”

That’s what happened to Tim Hanson’s beloved cat, Kira, who died in February after eating raw food from a company called Wild Coast. The company has recalled the product, Boneless Free Range Chicken Recipe. It’s one of four recalls in the last month alone.

Hudson is suing Wild Coast for the veterinary bills — about $8,000 — and said he was devastated that Kira, whom he called “the happiest cat,” is gone. He said he thought he was doing right by her by feeding her the expensive raw food, but now urges people to avoid feeding their cats raw food at all costs.

“I don’t want any more cats dying,” he said. “Hopefully people can learn from Kira’s passing.”

Top image via Pexels. All other images via Wikimedia Commons

Wordy Wednesday: Critically Endangered Orangutan Babies

The palm oil and logging industries have killed so many orangutan mothers, there are now more than a dozen major orangutan orphanages in Borneo and Sumatra. The pressure on orangutans, with whom we share 97% of our DNA, shows no signs of abating.

Orangutans are critically endangered, and the biggest threat to their continued existence comes from the agricultural sector, which has razed 55 percent of the species’ habitat in recent decades.

Jarang, a baby orangutan born in 2023. Credit: Blackpool Zoo

Logging companies clearing irreplaceable, old-growth jungle to claim more land for palm oil plantations have no compunction when it comes to flattening jungles despite the presence of orangutans hiding in the trees. The loggers often shoot the large apes on sight, leaving terrified, traumatized babies still clinging to their dead mothers, or taking them to sell as pets.

Of those left to die, the lucky babies are rescued before they starve and are brought to one of the many orangutan orphanages in Borneo and Sumatra, where they attend “school” to learn how to do everything from climb to forage. It takes at least eight years to teach them how to survive on their own, which is about the time it takes orangutan mothers to do the same job in the wild.

The unlucky babies end up as local pets, sold off to entertainment troupes or shipped off to places like Dubai, where wealthy clients will pay a premium for them.

Caretakers must start by teaching rescued orphans the most basic things, like how to climb and move through the jungle Credit: Borneo Orangutan Survival Foundation
Logos, an orphaned baby orangutan who was rescued in 2023 by the Jakarta Animal Aid Network (JAAN) Credit: International Animal Welfare Fund (IAWF)
Baby Galaksi (Indonesian for galaxy), was found wandering the jungle without his mother in 2021 by a villager in Borneo. He’s now in a “school” that teaches orphaned orangutans how to do everything from evading predators to discerning edible fruit from harmful and poisonous varieties. Credit: Samboja Lestari Orangutan Rehabilitation Centre

So what is palm oil, and why are countries in Asia bulldozing ancient jungles and forests to clear room and make more plantations?

Per the WWF:

“Palm oil has been and continues to be a major driver of deforestation of some of the world’s most biodiverse forests, destroying the habitat of already endangered species like the Orangutan, pygmy elephant and Sumatran rhino. This forest loss coupled with conversion of carbon rich peat soils are throwing out millions of tonnes of greenhouse gases into the atmosphere and contributing to climate change. There also remains some exploitation of workers and child labour. These are serious issues that the whole palm oil sector needs to step up to address because it doesn’t have to be this way.

Palm oil is in nearly everything – it’s in close to 50% of the packaged products we find in supermarkets, everything from pizza, doughnuts and chocolate, to deodorant, shampoo, toothpaste and lipstick.”

Palm oil is in constant demand, and it’s an easy to grow, incredibly efficient crop. Indonesia and Malaysia, the only two countries in the world where orangutans exist, produce 85 percent of the world’s palm oil.

Images of orangutan babies in wheelbarrows are common on social media, but usually stripped of context. Orphanages use the wheelbarrows to bring infants and toddlers to and from “school” every day. Credit: International Animal Rescue
Asoka was found crying in the jungle by a fisherman in Borneo. He was brought to an orphanage in Borneo. Credit: International Animal Rescue’s rehabilitation Centre in Ketapang, West Kalimantan

We share 97 percent of our DNA with orangutans, making the species our second-closest cousins from a genetic standpoint. Some studies claim orangutans are our closest relatives based on our phenotypical similarities.

Orphaned orangutans attending “school” to learn how to survive in the wild. Credit: Borneo Orangutan Survival Foundation
A baby at an orangutan orphanage is fed by a caretaker. Credit: Borneo Orangutan Survival Foundation

Want to read more and learn how to help?

Here are some links to get you started. PITB is a big fan of the Jakarta Animal Aid Network, which successfully pushed Jakarta’s municipal government to ban the incredibly cruel “topeng monyet” monkey street shows:

World Wildlife Fund: Orangutans
Jakarta Animal Aid Network
Borneo Orangutan Survival Foundation
The Orangutan Project
Rainforest Trust

Flow’s Cat Accepts Oscar In The Most Feline Way Imaginable

The animated feature about a cat surviving an apocalyptic flood has racked up awards and earned universal acclaim.

It’s been quite a year for Latvian animator Gints Zilbalodis and Cat, the star of Flow.

Their film won an Oscar for best animated feature film, racked up wins at the Golden Globes and smaller film festivals, became the most-watched film in Latvian history, snuggled its way into the hearts of audiences in the US, Europe and Asia, and enjoys incredibly rare universal accolades from critics and viewers alike, scoring 97 and 98 percent with each group respectively on film review site Rotten Tomatoes.

Now Cat has officially recognized his Oscar by doing precisely what his species loves to do. In a short video posted by Zilbalodis, Cat smacks the golden statue off the railing of his boat and onto the deck, to the annoyance of his lemur buddy.

Congratulations, Gints and Cat!

Shrill Editorial Calls Cats ‘Domestic Terrorists’ And ‘Skulking, Disobedient Destroyers’ Who Should Be ‘Locked Down’

The more bunk studies claim cats are driving wildlife to extinction, the more people in media and government call for extreme measures to contain them.

Seventy nine cats.

That’s how many felines stood in for the entirely of the UK in a 2022 study, which is the genesis for the claim that cats kill 270 million birds and small animals in that country.

Using GPS collars, owner questionnaires and samples of prey brought home by those 79 outdoor cats, a research team from the University of Reading applied data from a mix of studies dating as far back as 23 years ago, extrapolated and massaged numbers using things like “kernel density estimates” and “generalized mixed models,” and came up with that 270 million figure, which is cited routinely and credulously by UK media.

Actually, their estimate was between 140 and 270 million. An earlier study put the number at 92 million, and a 2016 study estimated UK cats kill 55 million birds and small animals. That’s a range of 215 million!

The Reading team even quotes the infamous US meta-analysis that claims domestic cats kill as many as 4 billion birds and 22.3 billion mammals a year here. That paper, as skeptics in the science community have noted, has virtually no relationship with reality, involves no original research, and relies on data from unrelated studies and surveys in which cat owners were asked to rate their pets’ hunting prowess on a point scale while imagining what the little ones get up to when they’re outside.

All of this is to say that aside from the thorough, labor-intensive and expensive D.C. Cat Count, which brought together cat lovers, birders and scientists to work cooperatively, the 2022 UK study and its counterparts in the US and Australia are exercises in pushing an agenda masquerading as honest academic research.

That’s how we get editorials like The Spectator’s “We need a cat lockdown now” by Zoe Strimpel. Though the tone isn’t tongue in cheek, I can’t imagine Strimpel dislikes cats nearly as much as she claims, and the post was probably written with wry anticipation for the click-generating fury of cat lovers indignantly sharing it on Facebook and X.

Still, it quotes the Reading study without skepticism and portrays cats as furry little wretches who abuse their human caretakers with their claws and their disdain while gleefully eating their way through endangered birds.

A cat stares down a mouse. Credit: Wikimedia Commons

Cats are predators, that much we can agree on, and outdoor cats are much more likely to negatively impact local wildlife, for obvious reasons.

Likewise, I can understand the concern with cat culture in the UK, where allowing pet cats to roam outside is the norm.

But every time the media cites the above-mentioned studies, more people are given an inaccurate impression of feline ecological impact, and more lawmakers at the local and national level consider “solutions” ranging from prohibiting people from keeping pet cats, as a government commission in Scotland recently proposed, or exterminating them outright, as some Australian states and municipalities in New Zealand have tried to do.

It’s worth pointing out that there is no data, not even a single study, showing that air-dropping poisoned sausages or arbitrarily shooting cats actually has any positive impact on birds and small mammals. All it does is terrorize sentient, intelligent domestic animals who have real emotions and experience real fear and pain.

The primary drivers of declining bird and small mammal populations — including habitat loss, environmental destruction, wind turbines and glass buildings — have nothing to do with cats. We have killed off 73 percent of the planet’s wildlife since 1970 and every species of iconic megafauna — from orangutans and gorillas to tigers and pangolins — is headed toward extinction. Are domestic cats responsible for that too, or can we be adults and fess up to our role as the main antagonist here?

An orange tabby and a mouse. Credit: Wikimedia Commons

Strimpel actually goes even further, claiming cats don’t have real affection for their caretakers and are more like psychopaths, faking love because it gets them what they want, primarily food and shelter.

Dogs have true affection for their humans but cats do not, she additionally claims, while adding that cat people are undateable because they share qualities with the “loutish and numerous creatures” they care for.

There was a time when I would have been ambivalent about Strimpel’s attitude toward cats, if not her cavalier treatment of basic facts. But then a drool-happy, friendly tuxedo cat showed me I could interact with his species without my allergies going haywire, and a tiny gray tabby kitten became my animal cognition teacher while blindsiding me with love.

Now every time I hear about some psychopath abusing cats, or terribly misguided politicians advocating a plan to kill millions of domestic felines, I think about my Bud. I think about how he cries for his Big Buddy when he’s hurt or stuck, how he meows and trills with excitement when he experiences something new, and how he began shaking, then threw up from overwhelming relief and happiness the first time I returned from a vacation after adopting him.

Buddy the Cat chillin’ on the balcony in the summer. Credit: PITB

He’s got a vibrant mind in his little head, with strong opinions and emotions. So does every cat on the street, in a shelter cage, and in the cross hairs of a birder or biologist playing God by “culling” or “harvesting” cats to protect another species.

Real science, not activism packaged as science, has proven that many times over in recent years. If people want to do harm to cats because they think birds and other animals will benefit, the burden of proof is on them to show not only that their methods work, but that the results could somehow justify the fear and misery they would inflict on innocent animals to achieve their goals.

Cats are obligate carnivores who don’t have a choice. We do.