Oh Oh Oh Ozempic For Our Oh Oh Oh Obese Cats? It’s Close To Reality

In apocalyptic news for house cats everywhere, a pharmaceutical company is kicking off a trial of a GLP-1 drug for felines.

If cats could read newspapers, chances are they’d be gripped by a cold terror right about now, wondering if they’re among the unfortunates to have their yums curtailed by the same weight loss drugs their humans have been gobbling.

As the New York Times reports, a biopharma company headquartered in San Francisco, Okava Pharmaceuticals, is about to begin a trial to determine if GLP-1 drugs can help our chonksters slim down. More than 60 percent of American pets are packing extra pounds, the Times notes, while consequences like diabetes are shortening the lifespans and reducing quality of life for felines and canines.

“It is our belief that the condition of obesity, the condition of being overweight, is by far the number one most significant preventative health challenge in all of veterinary medicine,” Okava founder and CEO Michael Klotsman told the paper.

The upcoming study will include 50 cats. Most will receive a GPL-1 medication while a control group — about one third of the cats — will be given a placebo.

Since cats aren’t exactly known for being cooperative when it comes to taking oral medicine and weekly injections at a veterinary office are impractical, Okava has developed a system with a patch about the size of a microchip that will dispense the weight loss drugs over six months before a tiny cartridge needs to be replaced.

If all goes well with the trial, Okava will seek FDA approval and address other obstacles like convincing caretakers that their little pals can benefit from the feline version of Ozempic, Mounjaro and Wegovy.

That may be easier said than done considering our relationships with our furry friends and the role food plays in things like training, bonding and every day life

For lots of cat caretakers “their main way that they interact with and show their love to their pet often revolves around food,” Dr. Maryanne Murphy, a veterinary nutritionist at the University of Tennessee, told the Times.

How could the dynamic between cat and human change if the flow of yums is reduced to meals only? Will training — for everything from walking on a harness, to entering a carrier and fun tricks like high fives — still work if the reward is just a bit of encouragement or a scratch behind the ear?

An earlier weight loss drug developed for dogs, Slentrol, did not catch on because, as one veterinarian noted, “the main way [people] interacted with their pet was by feeding them, and seeing their excitement and happiness when they were eating the food.”

There’s also the not-so-small matter of cost. GLP-1 drugs are in high demand, and they’re expensive. One in eight Americans has taken Ozempic or one of its competitors. At times, the demand has threatened availability for diabetics, for whom the drugs were developed in the first place.

If the trials are successful and the GLP-1 drugs for pets gain FDA approval — which would require a series of much larger scale, more rigorous studies — the company hopes to offer them to consumers at a cost of about $100 per month per pet.

Even if this iteration of the drug fails, it’s unlikely to derail the larger effort. Vets have been prescribing tiny doses of the human version to cats with diabetes, and perhaps most telling of all, pet obesity continues to rise despite years of efforts by the veterinarian community to get people to play with their pets more and feed them less.

As Dr. Ernie Ward, a veterarian and founder of the Association for Pet Obesity Prevention, told the paper: “We haven’t moved the needle.”


And now we check in with our correspondent, Buddy the Cat. Buddy, what do you think about the possibility of GLP-1 for your species and the end of the proverbial gravy train?

Buddy? Bud? Are we having technical difficulties?

I’m sorry, ladies and gentlemen, we can’t find Buddy the Cat. We’ll resume this segment if and when we manage to locate him.

Do You Speak Cat? This Quiz Tests Knowledge Of Real Feline Language

Studies show most of us are pretty bad at interpreting our cats’ moods. A research team in Australia wants to change that.

Cats are constantly telling us how they feel, but many of us aren’t listening.

We’re not talking about chirping, trilling and meowing, although those are some of the ways our cats try to communicate with us.

While they might seem protective of their own thoughts and feelings, cats are actually transparent, and they can’t lie.* Their tails, ears, whiskers, facial expressions and body language all broadcast a cat’s mood.

The question is, are we picking up that broadcast?

In The Conversation, the University of Adelaide’s Julia Henning introduces us to a quiz she designed to answer that question, and invites us to take it.

The goal: to correctly assess each cat’s mood. What I liked most was that we’re asked to evaluate videos — clear, well-lit high resolution clips — instead of the low resolution stills that are often used for quizzes like this.

Sir Talks-a-lot

Henning has been studying the human-cat communication issue because when we misread cats, there’s a good chance we’re stressing them out. Henning and her team published the results of a study in September in which 368 participants from Australia were asked to evaluate a series of clips human-feline interaction.

It turns out they didn’t do so well at reading the signs that a cat is agitated, stressed or doesn’t want to play.

“For videos of cats who weren’t playing and were showing subtle negative cues (such as sudden tension in the body or avoiding touch), participants only recognised the negative cues about as well as chance (48.7%),” the authors of the study wrote.

Even when study participants correctly read a cat’s ears, tail, whiskers and body language, some of them indicated they’d do things that would unknowingly make a cat more agitated and stressed. A classic example is trying to pet a cat’s belly and misinterpreting their derpy way of trying to block you as a playful gesture.

Did you know? Approximately 96% of Buddy’s communication is related to yums.

In the paper, which was published in Frontiers in Ethology, Henning and her colleagues lay out the case for making sure we — the people who take care of cats — are sensitive to what our little buddies are feeling.

It’s not just about strengthening the bond, although that’s an important part. It’s about reducing stress and miscommunication, and increasing quality of life.

Cats are incredibly sensitive to our actions and moods because we are the most important living beings in their lives. We feed and house them, and we’re their pals. If we’re constantly subjecting them to play they don’t like or overstimulating them, they get stressed, and stressed cats can become depressed, sick or resentful cats.

If we want to make sure our buddies live their best lives, we have to understand what they’re trying to tell us.

(*) Except when it comes to food. When food is involved, these innocent, cute little furry creatures become master manipulators and can convince anyone they’re starving.

Note: The first version of this story linked to the study page twice when the first link should have pointed to the quiz. It’s fixed now, and email subscribers can follow the link through this version of the story. Apologies for the error.

Header image credit: cottonbro studio/Pexels

When Cute Is Cruel: Breed Beloved By Celebrities Like Taylor Swift Suffers Painful Genetic Mutation

Scottish Folds are cute, but the genetic mutation responsible for their folded ears also causes lifelong pain, joint problems and misshapen bones.

In 1961, a shepherd named William Ross found a barn cat with a curious feature: instead of the upright, swiveling, satellite dish ears of a normal feline, this cat’s ears were floppy and shapeless, resting atop her head like a tiny knitted cap.

Ross took the cat home and named her Susie. Susie gave birth to a litter of kittens with the same floppy ears, and it all gets a bit murky from there, with a dozen variations of the story online claiming it was Ross himself or a neighbor who “created” the breed.

Regardless of who it was, the floppy ears were transformed from an abnormal feature into the unmistakable characteristic of a breed, and the Scottish Fold was born.

The cute cats quickly caught on and were officially recognized in competitions by 1971.

Now they’re more in vogue than ever. They’re the preferred pets of music superstars Taylor Swift and Ed Sheeran, who regularly feature photos and videos of their Scottish Folds in social media posts. People across the world are buying them, and they routinely appear in “best breed” lists online, lauded for being cuddly and docile in addition to adorable.

Ed Sheeran with his Scottish Fold cat
Ed Sheeran with his Scottish Fold cat. Credit: Ed Sheeran/Instagram

But they’ve also been banned by the same cat fancy groups that initially welcomed them, they’re prohibited outright in some countries, and animal welfare groups are begging people to stop emulating celebrities by buying them.

That’s because the same deformity that gives Scottish Folds their distinctive ears is also responsible for weak and brittle cartilage and bones elsewhere in the body, which results in lifelong pain and disability.

According to the RSPCA:

“The disease is evident on x-rays of cats from as young as seven weeks of age. Serious abnormalities in joints and bone growth lead to arthritis (painful, swollen joints), short, abnormally thick, and inflexible tails, spinal abnormalities and short, stiff legs. The welfare impacts of Scottish Fold Osteochondrodysplasia can be severe in terms of pain and inability to perform natural behaviours, as these cats can be lame, walk with an abnormal gait, can be reluctant to engage in normal movements such as walking or jumping, and can even become completely crippled.

There is no cure for this progressive condition.”

Sadly, the deformities and resulting pain may be the reason Scottish Folds are considered docile and cuddly: they may simply be in too much pain to move or protest when their humans hug them or pick them up.

Ross and Turner didn’t know it in 1961, but the folded ears and brittle cartilage were the result of a genetic mutation. It wasn’t until 2016 that a group of American and Australian scientists found a mutation in a single gene, TRPV4, was responsible for weak cartilage and bones, leading to the deformities highlighted by the RSPCA in the passage above, as well as “progressive joint destruction.” The condition is called osteochondrodysplasia.

Taylor Swift and Scottish Fold cat
Swift’s cats have appeared in her music videos, feature prominently in her online posts, and were photographed in her arms for her 2024 post announcing she was supporting Vice President Kamala Harris in November’s presidential election.

Cats Protection, a UK charity, raised the issue in 2024, warning that Scottish Folds were becoming even more popular, with breeders struggling to meet high demand. The group issued a public statement asking cat lovers and Swift fans to avoid buying Scottish Folds. Scottish Folds are equally popular in the US, spurring resistance from stateside animal welfare groups as well.

The Governing Council of Cat Fancy, which registers breeds in the UK — and no longer recognizes Scottish Folds — was even more direct.

“We strongly advise members of the public not to try to acquire cats of this breed,” Steve Crow, chairman of Cat Fancy’s governing board, told The Guardian.

Massachusetts Becomes 3rd State To Ban Declawing

The Massachusetts law is a significant victory in the quest for a national ban on the cruel procedure, which involves amputating cat toes at the first knuckle

There’s good news today from Massachusetts, which just joined New York and Maryland in banning cat declawing.

The bill, signed Friday by Massachusetts Gov. Maura Healey, prohibits all declawing surgery except for rare circumstances when it’s medically necessary, like cancer in the nail bed.

Veterinarians who violate the law face fines up to $2,500 and professional discipline if they continue the practice.

Despite its name, declawing is the partial amputation of cat toes, equivalent to cutting off human fingertips at the last knuckle.

a little cat playing
Photo credit: Alex Ozerov-Meyer/Pexels

Declawing changes a cat’s gait, causing the animal pain when it walks, and usually leads to early arthritis. It causes cats to stop using their litter boxes, because the act of standing on and shoveling litter becomes painful for them.

Last but not least, it has a profound psychological impact on felines, making them vulnerable by taking away their primary form of defense. Consequently, cats who are declawed are much more likely to bite than those with intact claws.

Most of all, declawing is cruel and inflicts a lifetime of pain on innocent animals, punishing them for doing what cats naturally do.

Aside from New York, Maryland and Massachusetts, a few dozen cities and counties have banned the procedure, ranging from places like St. Louis, Missouri, to Austin, Texas, and eight cities in California, including Los Angeles and San Francisco.